What is sickle cell anaemia

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Sickle cell anaemia:- 
  Sickle cell anaemia is a syndrome in which the insoluble haemoglobin precipitates in the red cells and the red cells assume a sickle
shape . Haemoglobin is a carrier protein . 
 When one amino acid is altered in the chain of the protein , from Glu ->Val, the haemoglobin protein become less soluble , especially when it is not carrying oxygen .

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